Pro-chondrogenic Propensity of Sticopus Chloronotus Aqueous Extracts on Human Osteoarthritis Articular Chondrocytes in Vitro
نویسنده
چکیده
Mohd Heikal MY*, Ahmad Nazrun S, Mohd Fauzi Busra, Chua KH, Norzana AG, Rizal AR 1. Department of Physiology Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. 2. Department of Pharmacology Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. 3. Department of Anatomy Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. 4. Department of Orthopaedic Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. 5. Tissue Engineering Centre, Kebangsaan Malaysia Medical Centre, Kuala Lumpur.
منابع مشابه
Comparison between Chondrogenic Markers of Differentiated Chondrocytes from Adipose Derived Stem Cells and Articular Chondrocytes In Vitro
Objective(s): Osteoarthritis is one of the most common diseases in middle-aged population in the world. Cartilage tissue engineering (TE) has been presented as an effort to introduce the best combination of cells, biomaterial scaffolds and stimulating growth factors to produce a cartilage tissue similar to the natural articular cartilage. In this study, the chondrogenic potential of adipose d...
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Background: Integrins are a family of transmembrane proteins that allow communication between the extracellular matrix and the interior of cells. Chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including mechanotransduction. Integrins are known to associate with a number of accessory molecules such as CD147 that may act to regu...
متن کاملComparison between Chondrogenic Markers of Differentiated Chondrocytes from Adipose Derived Stem Cells and Articular Chondrocytes In Vitro
OBJECTIVE(S) Osteoarthritis is one of the most common diseases in middle-aged population in the world. Cartilage tissue engineering (TE) has been presented as an effort to introduce the best combination of cells, biomaterial scaffolds and stimulating growth factors to produce a cartilage tissue similar to the natural articular cartilage. In this study, the chondrogenic potential of adipose deri...
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Articular cartilage is characterized by the lack of blood vessels and has a poor self-healing potential. Limited cell numbers and dedifferentiation of chondrocytes when expanded in vitro are the major obstacles of autologous chondrocyte implantation. Autologous chondrocyte implantation is a cell-based treatment that can be used as a second-line measure to regenerate chondral or osteochondral de...
متن کاملThe Expression of Signal Regulatory Protein-alpha in Normal and Osteoarthritic Human Articular Cartilage and Its Involvement in Chondrocyte Mechano-transduction Response
Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...
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